EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
3.1.3.75 | additional information | generation of phospho1-R74X-null mutant, i.e. Phospho1-/-, mice by N-ethyl-N-nitrosourea mutagenesis | Mus musculus |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.1.3.75 | Mus musculus | Q8R2H9 | - |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
3.1.3.75 | bone | - |
Mus musculus | - |
3.1.3.75 | tibia | - |
Mus musculus | - |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.1.3.75 | PHOSPHO1 | - |
Mus musculus |
3.1.3.75 | phosphoethanolamine/phosphocholine phosphatase | - |
Mus musculus |
EC Number | General Information | Comment | Organism |
---|---|---|---|
3.1.3.75 | malfunction | long bones from Phospho1-/- mice do not fracture during 3-point bending but deform plastically. With dynamic loading nanoindentation the elastic modulus and hardness of Phospho1-/- tibiae are significantly lower than wild-type tibia. Mutant mice show significantly lower mineral:matrix ratios and lower carbonate substitutions in Phospho1-/- tibia, phenotype, overview | Mus musculus |
3.1.3.75 | physiological function | PHOSPHO1 is a phosphoethanolamine/phosphocholine phosphatase involved in the generation of inorganic phosphate for bone mineralization | Mus musculus |